Uncertainty and doubt are two elements that are bound to disrupt the foundation of any loving relationship. Guddu is a story of certain relationships that are fuelled by the fire of doubt. Gohar is a young woman who along with her son Guddu leads a blissful and happy life. Despite living away from her husband Ibad, Gohar has never complained about any discomfort. Living in harmony with her in-laws, Gohar is close to her sister-in-law Sidra and both of them share a relationship of love and respect. Soon the arrival of Ibad brings a new wave of happiness for the whole household while an uncertain difficulty arises for Gohar. In efforts to help Sidra overcome a situation, Gohar's naive nature and Ibad's mistrust in Gohar leads to unfortunate circumstances. As their relationships begin to weaken, people close to them disappear as well. Amidst an increase in differences between Gohar and Ibad, what does the future holds for Guddu? Will Gohar be able to defend herself and prove her innocence? Will Ibad and Gohar be able to provide a loving and secure life to Guddu ahead?