Half-witted longtime friends Albert (Luis Manzano), Isaac (Billy Crawford), Mozart "Mo" (DJ Durano), Michaelangelo "Mike" (Martin Escudero), and Aristotle "Aris" (Marvin Agustin) were used to living moronic, yet pretty normal and hassle-free lives until successful career woman Becky Pamintuan (John Lapus) accuses them of killing her father and ruins everything for them. The Moron 5 are more than sure of their innocence but they can't find a single satisfactory argument on how to prove it, especially when their opponent would do everything to punish them for whim. Spending three miserable years in prison trying different failed comedic attempts to get out, they finally figure out a way to escape. They stalk Becky and try to understand why she's fighting so hard to have them imprisoned when it's clear as day that what happened three years ago was a nonsense frame-up. An opportunity comes when Becky's driver gets fired for having an affair with her maid and Albert volunteers to apply to replace him. He infiltrates the Pamintuan Residence, and together with his four crazily daft friends, they gather information about the curious family, yet little of it makes sense, especially Becky's hatred for the quirky quintet. Why is Becky fighting so hard to have them suffer? The Moron 5 will try their hardest to know and hopefully understand what's going on--but by doing so, everything they hold dear might be at risk.