Childhood best friends who are both geniuses in school eventually become bittersweet rivals for campus athlete Mark Ferrer. Zoe Tuazon is a rich, overweight and aggressive mestiza; Aica Tabayoyong is a poor, nerdy, nearsighted student with a bad case of teenage acne. In an effort to outsmart and outclass each other, Zoe and Aica each undergo cosmetic surgery and become ravishing vixens engaged in ugly confrontations.