Ashley Shields has had a rough year following the death of her mother, the disintegration of her marriage, and getting passed over for a promotion at work. So when her sister Jasmine brings her to a women's group, The Sisterhood, she is intrigued, and hopes to feel empowered enough to change her life. Led by the enigmatic and charismatic Desiree, The Sisterhood delivers to Ashley everything it promises. She gets a raise at her job, her divorce is resolved in her favor, and she finally feels fulfilled and happy. But she soon discovers that the benefits of The Sisterhood come at a steep--and sometimes illegal--price. As she learns more about The Sisterhood and is forced to participate in its questionable activities, she realizes that she is in over her head and must get out--even if it's at the expense of her relationship with Jasmine--or at the cost of her life.