In pursuit of a gang of violent but charismatic criminals, Officer Charlotte Briggs finds herself caught in twisted game of life and death where the rules are always changing, and the House always wins. An abandoned missile facility deep in the Arizona desert becomes a labyrinthian house of horrors as Officer Briggs pursues a dangerous gang of bank robbers led by the vicious but oddly principled Ronin. It isn't long before the doors are sealed behind them and a mysterious voice begins to question and challenge them. The mysterious Overseer forces our heroes (and antiheroes) deep into a subterranean facility populated by monstrous mutants. In a bloody and terrifying fight for survival, friends become enemies and vice versa, as the Overseer pushes his new "subjects" to their very limits and beyond.