Based on the American series 'New Amsterdam,' the series will follow the events that subsequently occur after an idealist doctor is assigned to a hospital in the city. Chief Physician Baris Güvener is appointed to Hisarönü Hospital, one of the oldest and most established hospitals in Istanbul. However, Hisaronu, one of the best hospitals of its time, is going through a difficult time. With the arrival of a young and idealistic chief physician, the story of the entire hospital begins to be rewritten. Baris tries to get the hospital up and running, he will not only struggle with the difficulties in his own life but also enter into a tough battle for his patients and his colleagues, whose hearts he wins over one after the other. While the path of impossible loves, precious friendships, and touching life stories passes through Hisarönü Hospital, Baris will make us believe again in the power of love, hope, and devotion and will open the doors of the hospital to everyone living in Istanbul. In order to say "Hayat Bugun" (Life is Today), to hope and start over, he will ask only one question; "How can I help you?"