When nursing student Esha is found brutally murdered and beheaded in her sublet room in the quiet neighborhood of Azimpur, the case shocks the local community. Newly assigned officer Lina (Azmeri Haque Badhon), recently transferred from the detective branch, takes charge of the investigation. Haunted by the trauma of childhood abuse, Lina confronts her past while diving deep into a case that's as disturbing as it is complex. The forensic report reveals two sets of DNA on the victim, along with evidence of multiple stab wounds and a surgically precise decapitation. As Lina begins to unravel Esha's life, she discovers a young woman juggling her nursing studies, a secret relationship with a neighborhood boy, and constant harassment-from a local thug, her landlord, and others around her-while trying to survive through private tutoring. Lina's investigation exposes multiple layers of motive and manipulation. But when a key suspect is suddenly murdered, pressure mounts from a patriarchal police administration that doubts Lina's capability. Detective Raihan is brought in to take over, quickly arresting Esha's lover and building a case that seems too convenient. With just 12 hours left before an official announcement pins the murder on the wrong man, Lina races to uncover the truth. Esha Murder: Karmaphal is not just a gripping thriller-it's a race against a cunning serial killer, and a critique of a system that too often fails women like Esha and Lina.