On the whole, I thought this was pretty lame, but I can see how certain people might enjoy it -- e.g., Catholic college kids, anyone under 18, or women (or gay men) who think Dane Cook is hot.
First, the compliments: it was interesting to see him perform "in the round", his physicality is admirable, and his ability to go from extremely clean (or even child-like) jokes to extremely vulgar jokes shows a nice range.
However, overall this just didn't do it for me. I hardly laughed at anything. Most of the jokes seemed to be the kind that a teenager might make up. His "observations" about relationships seemed like they were made by someone who had been in maybe 2 relationships, neither of which lasted more than 6 months -- yet he used the words women "always" do such-and-such, men "always" do whatever. Always? Really? His over-the-top descriptions of how men and women argue seemed completely false.
Many other jokes just missed the mark for me, such as the bit about crying - and the implication that "everyone" needs a good cry. Sure, I cry at certain things, but I never need a "good cry." I am not trying to sound tough here, it's just that I don't know any adult men that come home from work, and just start bawling because they wanted to cry their hearts out all day long. Therefore, I chuckled at the jokes, although I was thinking that it had nothing to do with any reality that I personally experience. Girls and young boys could probably relate.
Another example - he brings a girl home and she starts masturbating, and he does too. He asks if she likes it and she, like other women, "always" says "ooooh yeah". The joke goes something like: "what if she said, thanks for asking, but no, I don't really want to see that." Are you wondering where the joke is? Me too. Some women enjoy seeing men *, and many do not. So, where is the humor? One last example - he refers to word "chit-chat" as "chat-chit" and then actually states something to the effect that he is very clever.
Overall, I just didn't relate to any of his self-absorbed humor, and the "observations" seemed to come from a world that I did not recognize. Although when I was in high school (20 years ago) and knew nothing about relationships or life, I probably would have liked it a lot more.