A Zombie curse is placed upon a woman, which causes her to have living snakes inside her. Brujo, who is looking after her, attempts to take her to Los Angeles on the train. After several confrontations on the train, Brujo's collection of snakes manage to separate themselves from their owner and go on the hunt. Whilst all this is happening, normal, everyday passengers are relaxing, what is unknown to them is that something deadly is heading their way, and that there is no way out.